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Clinical studies consistently report elevated circulating and central levels of pro-inflammatory cytokines, including interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor- (TNF-), in patients with major depressive disorder, with cytokine concentrations often correlating with symptom severity, illness chronicity, and treatment resistance (30, 32)

Eldehni, M

Cagrilintide is the most evidence-anchored option because CagriSema shows that adding amylin to a GLP-1 backbone improves outcomes

Unfortunately, this only compounds the effects

While the body has systems in place to repair damaged cells, persistent oxidative stress overwhelms those mechanisms, setting off a chain reaction of cellular dysfunction